To inadequate absorption and synthesis of vitamin K (as in obstructive jaundice, biliary fistula, ulcerative colitis, intestinal Secondary to administration of oral antibiotics, quinidine, quinine, salicylates, sulfonamides, excessive vitamin A, and secondary Reportedlyĭemonstrates wide margin of safety when used in newborns.ĭrug of choice as antidote for overdosage of coumarin and indandione oral anticoagulants. Does not reverse anticoagulant action of heparin. Promotes liver synthesis of clotting factors by unknown mechanism. Vitamin K is essential for hepatic biosynthesis of blood clotting Factors II, VII, IX, and X. PHYTONADIONE (VITAMIN K1) PHYTONADIONE (VITAMIN K 1)ĪquaMEPHYTON, Konakion, Mephyton, PhylloquinoneĬlassifications: hormones and synthetic substitutes vitamin antidoteĥ mg tablets 2 mg/mL, 10 mg/mL injection Actionsįat-soluble naphthoquinone derivative chemically identical to and with similar activity as naturally occurring vitamin K.
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